on combined T4/T3 therapy, or feeling better on thyroid meds
Important Disclaimer: I am not a doctor. I am a thyroid cancer patient. None of what follows is intended to provide medical advice, only food for thought, and perhaps some useful information for other thyroid patients to bring to the attention of their own doctors.
Nearly all hypothyorid and thyroid cancer patients are treated with T4 hormone replacement alone, almost always the name-branded Synthroid, sometimes Levoxyl. There is, however, another hormone produced by the thyroid gland, T3; a synthetic version of T3 called Cytomel is readily available. Yet by far the vast majority of thyroid hormone replacement users have never been treated with T3. Why not? The subject comes up two or three times a month over on the Yahoo! Thyroid Cancer Support Group, and it usually goes something like this: My endo says my levels are fine, but I still feel crummy. Has anyone tried combined T4/T3 therapy?
Every time I see that reliably controversial topic raised, I get annoyed. Not at the poor innocent who has posted the question, but at the endocrinology industry that continues to screw around with hapless hypothyroids and thyroid cancer patients, year after year. So if you're searching for answers on combined T4/T3 therapy, you may find some here.
Endocrinologists avoid prescribing T3 as if it were pathological, completely ignoring the fact that normal functioning thyroids do indeed produce it. They usually cite three issues with T3, as follows:
1) it's not necessary, since all cells in the body can convert T4 into T3 as needed; 2) it's dangerous, since overdose can produce thyrotoxicosis, with symptoms including palpitations and high blood pressure; and
3) it's not as effective, since its half-life is so short (one day, as opposed to 7 days for synthetic T4.)
To these issues, I offer these common sense rebuttals:
1) If it weren't necessary at all, why would normal healthy thyroids make it in the first place? Also, the fact that people can survive without it is not dispositive of the supposition that they could do better with it. This is, at heart, a quality of life issue.
2) It is true that overdose can produce very serious problems, but these same problems can be caused by overdose of T4. Saying "it's too dangerous!" is just silly. If we were to follow that logic, no one would ever get thyroid hormone replacement treatment, and I'd be dead right now. Pharamacists hand over deadly medications to patients millions of times a day, and yet no one questions the practice -- because doctors write appropriate prescriptions for their patients. I really think endocrinologists should give themselves more credit.
3) Ah, the half-life issue. T3 is more rapidly metabolized, and so it is harder to get a nice, even supply of T3 into the bloodstream if the patient wishes to take a single dose once a day. The solution is, of course, time-released T3, which can be easily prepared by a compounding pharmacy. Some patients have no difficulty in splitting their T3 doses over the course of a day to maintain an even keel, so to speak. But some combined T4/T3 patients (like me) have no problems whatsoever taking all their meds at one time each day -- the T4, with its longer half-life, helps keep the overall level of thyroid hormone stable.
In spite of these counter-arguments, the established endocrinology community continues to spurn combined T4/T3 therapy. For an example of those holding the prevailing opinion, take Dr. Kenneth B. Ain, author of the generally superb and only somewhat condescending The Complete Thyroid Book. I "know" Dr. Ain from his frequent contributions to the above-mentioned online support group, and let me tell you: he has apparently infinite patience for repetitive questions but not much for stupidity, and he'll come right out and tell you if what you're talking about makes no sense whatsoever. I appreciate having a straight-shooting professional out there making sure the group doesn't wander too far afield, and I recognize that Dr. Ain's contributions to the group are invaluable. He has many years of thyroid and thyroid cancer treatment experience, and there's no one else in the group who comes close to having his level of authority because of it.
But along with that authority there often comes a kind of arrogance. And so it is with Dr. Ain, at least with respect to the combined T4/T3 question. Here we find him completely dismissing the possibility of combined therapy's use for thyroid cancer patients:
But what about Dr. Ain's assertion regarding all that research? I think that while Dr. Ain's opinon is supported by whatever research is out there, that doesn't mean that the research itself was properly or even honestly done -- that is, without a pre-set agenda to prove or a sponsor to please. Recent reports on the inaccuracy of scientific research would seem to support my position.
But what I really don't understand about Dr. Ain's opinion (which is, remember, exactly the same thing as the mainstream opinion) is that even he readily recognizes that:
This issue eerily parallels the cheerful pronouncements of mid-20th century doctors who declared that evaporated milk and early baby formulas were just as good as mother's milk, and as a result, nursing became stygmatized as "low class" or "poor". Yet now as each year goes by, formulas are newly fortified with yet-another essential nutrient that has been identified in mother's milk. So, when is the medical establishment going to learn that natural human phsyiology should be the model on which treatment is based?
Combined T4/T3 may not be required for good health, but if a patient isn't feeling well on his current therapy, why not give it a try? Some people may fare better on straight T4 therapy, and if they feel well, there is no reason to change. But for the many hypothyroid or thyroid cancer patients who continue to feel less than optimal, combined therapy could help them feel better.
So what if you want to try it?
There are a number of practitioners who do "believe in" combined T4/T3 therapy, if only because they believe the evidence of their own eyes: patients who report to fewer symptoms and more well-being when on the therapy than not. In addition to the above-mentioned Drs. Lowe and Shames, one proponent of combined therapy is Dr. Larrian Gillespie, The Hormone Diva. In her book, You're Not Crazy, It's Your Hormones, Dr. Gillespie says:
Now you'll just have to convince your endo to let you try it. You'll also have to pay more, because Cytomel is never a covered drug on medical insurance in my experience. But you just might feel better.
A bit on Thyroid Hormone Intolerance
When I was first diagnosed hypothyroid,I was put on a straight T4 therapy. I felt so horrible, I literally told my doctor, "I don't want to live this way." It is true that there is no such thing as "thyroid hormone intolerance." You can't be intolerant to thyroid hormones, we all need them to live. But what can happen is a kind of systemic attack (for lack of a better word) if you have an underlying condition that leads to problems when you start supplementing with thyroid hormones. Symptoms include: insomnia, headaches up to and including migraines, palpitations, and muscle and joint aches. Two conditions that can cause these symptoms when thyroid hormone supplementation is introduced are anemia and adrenal fatigue. The T4 prescribing information warns about these two conditions, but doctors never test before writing out the scrips. Seriously, they don't, so you'll have to look out for yourself.
On the anemia, it's iron stores that are most important here; Dr. Gillespie advises targetting serum ferritin around 100.
Unfortunately, most endos brush off the idea of adrenal fatigue-- if you don't have Addison's Disease or Cushings Syndrome, those adrenals must be fine! Why is there no middle ground with these docs? They'll readily treat a thyroid that's only limping along at half-capacity, or give progesterone or testosterone when those are testing out low. There's just huge skepticism over the idea that adrenal function could be sorta-OK, but not exactly right. So adrenal fatigue can be hard to diagnose, and it's controversial to treat, too. But unless your adrenals are OK, thyroid hormones are going to make you feel horrible. Check out the "adrenal fatigue" link above if those symptoms sound familiar.
So you can see there a number of reasons you can feel crummy while on thyroid hormone replacement. Look into these two conditions first, and once you know you're OK, if you're still not feeling your best, give the combined T4/T3 therapy a try.
Additional Resources
Mary Shomon's indispensible site, Thyroid Disease on the About.com network.
Mary's book, Living Well with Hypothyroidism
Richard L. Shames and Karilee Halo Shames, Thryoid Power Ten Steps to Total Health
Nearly all hypothyorid and thyroid cancer patients are treated with T4 hormone replacement alone, almost always the name-branded Synthroid, sometimes Levoxyl. There is, however, another hormone produced by the thyroid gland, T3; a synthetic version of T3 called Cytomel is readily available. Yet by far the vast majority of thyroid hormone replacement users have never been treated with T3. Why not? The subject comes up two or three times a month over on the Yahoo! Thyroid Cancer Support Group, and it usually goes something like this: My endo says my levels are fine, but I still feel crummy. Has anyone tried combined T4/T3 therapy?
Every time I see that reliably controversial topic raised, I get annoyed. Not at the poor innocent who has posted the question, but at the endocrinology industry that continues to screw around with hapless hypothyroids and thyroid cancer patients, year after year. So if you're searching for answers on combined T4/T3 therapy, you may find some here.
Endocrinologists avoid prescribing T3 as if it were pathological, completely ignoring the fact that normal functioning thyroids do indeed produce it. They usually cite three issues with T3, as follows:
1) it's not necessary, since all cells in the body can convert T4 into T3 as needed; 2) it's dangerous, since overdose can produce thyrotoxicosis, with symptoms including palpitations and high blood pressure; and
3) it's not as effective, since its half-life is so short (one day, as opposed to 7 days for synthetic T4.)
To these issues, I offer these common sense rebuttals:
1) If it weren't necessary at all, why would normal healthy thyroids make it in the first place? Also, the fact that people can survive without it is not dispositive of the supposition that they could do better with it. This is, at heart, a quality of life issue.
2) It is true that overdose can produce very serious problems, but these same problems can be caused by overdose of T4. Saying "it's too dangerous!" is just silly. If we were to follow that logic, no one would ever get thyroid hormone replacement treatment, and I'd be dead right now. Pharamacists hand over deadly medications to patients millions of times a day, and yet no one questions the practice -- because doctors write appropriate prescriptions for their patients. I really think endocrinologists should give themselves more credit.
3) Ah, the half-life issue. T3 is more rapidly metabolized, and so it is harder to get a nice, even supply of T3 into the bloodstream if the patient wishes to take a single dose once a day. The solution is, of course, time-released T3, which can be easily prepared by a compounding pharmacy. Some patients have no difficulty in splitting their T3 doses over the course of a day to maintain an even keel, so to speak. But some combined T4/T3 patients (like me) have no problems whatsoever taking all their meds at one time each day -- the T4, with its longer half-life, helps keep the overall level of thyroid hormone stable.
In spite of these counter-arguments, the established endocrinology community continues to spurn combined T4/T3 therapy. For an example of those holding the prevailing opinion, take Dr. Kenneth B. Ain, author of the generally superb and only somewhat condescending The Complete Thyroid Book. I "know" Dr. Ain from his frequent contributions to the above-mentioned online support group, and let me tell you: he has apparently infinite patience for repetitive questions but not much for stupidity, and he'll come right out and tell you if what you're talking about makes no sense whatsoever. I appreciate having a straight-shooting professional out there making sure the group doesn't wander too far afield, and I recognize that Dr. Ain's contributions to the group are invaluable. He has many years of thyroid and thyroid cancer treatment experience, and there's no one else in the group who comes close to having his level of authority because of it.
But along with that authority there often comes a kind of arrogance. And so it is with Dr. Ain, at least with respect to the combined T4/T3 question. Here we find him completely dismissing the possibility of combined therapy's use for thyroid cancer patients:
The only role of T3 for people with thyroid cancer is for the temporary preparation and recovery from hypothryodism for radioiodine treatment, thyroglobulin tests, and scans. (Complete Thyroid Book, p 152)And here we find him repeating the Standard Line Against T3 as I described above:
The only small study suggesting T3 supplemention of levothyroxine therapy for hypothyroidism was flawed and could not be verified or replicated by several larger studies done thereafter. T3 can make you thyrotoxic, which can be dangerous, as we discuss in Chapter 4. Since all hypothyroid people on T4 will make T3 because of the laws of biology and biochemistry, adding T3 is not helpful and could be harmful. [...] [P]hysicians cannot ethically recommend a therapy that could be potentially harmful when there is no perceived benefit. (p. 244)These two brief quotes more than adequately summarize Dr. Ain's feelings about the use of T3. There is no benefit to hypothyroid people in its use, he says, and in fact it could be harmful. Happily, there's a considerable amount of professional, medical disagreement with Dr. Ain's position, but it's all rather "below the surface" -- rarely published in the journals. Dr. John Lowe and the Dr. Richard Shames have both discussed their problems with the newer studies which refute the contention that adding T3 to a hypothyroid patient's therapy was beneficial. I'm not a doctor but I am extremely familiar with the kinds of study bias, bad design, and selective reporting of facts that Lowe and the Shames are describing here, and I still think that combined T4/T3 therapy is a good idea.
But what about Dr. Ain's assertion regarding all that research? I think that while Dr. Ain's opinon is supported by whatever research is out there, that doesn't mean that the research itself was properly or even honestly done -- that is, without a pre-set agenda to prove or a sponsor to please. Recent reports on the inaccuracy of scientific research would seem to support my position.
But what I really don't understand about Dr. Ain's opinion (which is, remember, exactly the same thing as the mainstream opinion) is that even he readily recognizes that:
The thyroid gland usually releases around 80 percent of its thyroid hormone as T4 and 20 percent as T3.(p 9)(emphasis added)You would think that if the normally functioning gland produces not just T4, but T3 as well in a non-insignificant amount, that fact alone would argue for combined T4/T3 therapy -- but not so.
This issue eerily parallels the cheerful pronouncements of mid-20th century doctors who declared that evaporated milk and early baby formulas were just as good as mother's milk, and as a result, nursing became stygmatized as "low class" or "poor". Yet now as each year goes by, formulas are newly fortified with yet-another essential nutrient that has been identified in mother's milk. So, when is the medical establishment going to learn that natural human phsyiology should be the model on which treatment is based?
Combined T4/T3 may not be required for good health, but if a patient isn't feeling well on his current therapy, why not give it a try? Some people may fare better on straight T4 therapy, and if they feel well, there is no reason to change. But for the many hypothyroid or thyroid cancer patients who continue to feel less than optimal, combined therapy could help them feel better.
So what if you want to try it?
There are a number of practitioners who do "believe in" combined T4/T3 therapy, if only because they believe the evidence of their own eyes: patients who report to fewer symptoms and more well-being when on the therapy than not. In addition to the above-mentioned Drs. Lowe and Shames, one proponent of combined therapy is Dr. Larrian Gillespie, The Hormone Diva. In her book, You're Not Crazy, It's Your Hormones, Dr. Gillespie says:
Now, remember the body "naturally" produces a ratio of 90% T4 to 10% T3 by weight...(You're Not Crazy, p27)(emphasis added)Dr. Gillespie says 10% by weight, whereas Dr. Ain says 20% of the hormones produced. Are they saying the same thing in different ways? I suspect so, because T4 is a larger molecule and so will take up a greater proportion of the whole by weight. Since Dr. Gillespie has had success in her practice using her dosage formula, you could use it as a starting point if you wish to bring this subject up with your own endocrinologist. You'll want approximately 10% of your total dosage to be delivered via T3, but since one microgram of T3 has the equivalent "strength" of 4 micrograms of T4, it's not as simple as splitting a 150mcg dose of T4 into 15 mcg of T3 and 135 mcg of T4! Dr. Gillespie offers this simpler formula for converting a straight T4 dosage into combined T4/T3 doses:
[D]ivide your T4 dose by 13. This will give you the amount of T3 for proper balance. Multiply the value by 9 for the [new] T4 level.(p. 29)Sounds easy enough, right?
Now you'll just have to convince your endo to let you try it. You'll also have to pay more, because Cytomel is never a covered drug on medical insurance in my experience. But you just might feel better.
A bit on Thyroid Hormone Intolerance
When I was first diagnosed hypothyroid,I was put on a straight T4 therapy. I felt so horrible, I literally told my doctor, "I don't want to live this way." It is true that there is no such thing as "thyroid hormone intolerance." You can't be intolerant to thyroid hormones, we all need them to live. But what can happen is a kind of systemic attack (for lack of a better word) if you have an underlying condition that leads to problems when you start supplementing with thyroid hormones. Symptoms include: insomnia, headaches up to and including migraines, palpitations, and muscle and joint aches. Two conditions that can cause these symptoms when thyroid hormone supplementation is introduced are anemia and adrenal fatigue. The T4 prescribing information warns about these two conditions, but doctors never test before writing out the scrips. Seriously, they don't, so you'll have to look out for yourself.
On the anemia, it's iron stores that are most important here; Dr. Gillespie advises targetting serum ferritin around 100.
Unfortunately, most endos brush off the idea of adrenal fatigue-- if you don't have Addison's Disease or Cushings Syndrome, those adrenals must be fine! Why is there no middle ground with these docs? They'll readily treat a thyroid that's only limping along at half-capacity, or give progesterone or testosterone when those are testing out low. There's just huge skepticism over the idea that adrenal function could be sorta-OK, but not exactly right. So adrenal fatigue can be hard to diagnose, and it's controversial to treat, too. But unless your adrenals are OK, thyroid hormones are going to make you feel horrible. Check out the "adrenal fatigue" link above if those symptoms sound familiar.
So you can see there a number of reasons you can feel crummy while on thyroid hormone replacement. Look into these two conditions first, and once you know you're OK, if you're still not feeling your best, give the combined T4/T3 therapy a try.
Additional Resources
Mary Shomon's indispensible site, Thyroid Disease on the About.com network.
Mary's book, Living Well with Hypothyroidism
Richard L. Shames and Karilee Halo Shames, Thryoid Power Ten Steps to Total Health
posted by Joan at 8:05 PM
8 Comments:
JO, this is a great ....send to editors..isnt it scary --amzing-- our capacity for investigating and learning even with so much other stuff we have to do... thank God for the internet --keep going!
Nicely done Joan - congratulations.
Well, you know I agree with you on the adrenal question. Hopefully I'll be getting that checked out within the next month.
Thank You! I "accidentally ran into your blog and am thrilled you are getting the word out.
I am 27 and have been tested for hypothyroidism every year since I was 10. After my second baby I could hardly function. I finally found a doctor who would treat my symptoms even though my blood tests are on the very low side of normal (using the old scale). A couple friends urged me to go and get a second opinion. I did and am still suffering the results. I let them convince me that a combo of T3/T4 was dangerous and have had my blood drawn 4 times this month and am completely off all medicine. I feel horrible and the new doctor won't treat me. I am going back to the "old school" doctor who treats symptoms (and my temp is usually 93 degrees)
Anyway, T3/T4 has been great for me with wonderful results.
I'll try to simplify the explanation here so to minimize possible confusion. The production of thyroid hormones involves iodine being attached to branches on the thyroglobulin molecule in the colloid. This is not a precise manufacturing process. As a result, some branches end up with one iodine atoms (called MIT) and some with 2 iodine atoms (DIT). In a second process, called coupling, that is also best described statistically, DIT and MIT branches are combined. MIT+DIT results in T3 and 2xDIT results in T4 (I am skipping other products here).
My point: one may view T3 as a by product of this in-exact production process. Yes, T3 is the biologically-active hormone, and it is fair to make a case that this T3 production is by design and not a by-product. Yet, no one has a definite answer.
My personal feeling: T3/T4 therapy is probably a fine idea as the body's ability to convert T4 into T3 may be over-taxed if no T3 is supplemented (this is my speculation).
About TSH: what is normal (based on statistical analysis) TSH for euthyroid at equilibrium is not necessarily the desired value for a hypothyroid. The reason is a bit complex: there's an intricate feedback system controlled thyroid hormone secretion via TSH. Once the thyroid gland is no longer acting normally, or completely deactivated, the feedback system, being a nonlinear process may have a different equilibrium point. I suspect this is why "normal" TSH values are off when it comes to hypothyroid cases.
I have been using a a t3/t4 combination in one form or another for nearly 1.5 years after being diagnosed hypothyroid. I used armour for about 9 months and then I went into approximately 90% t4 to 10% t3 ratio using a compounded time release of armoour extract. I tell you this with certainty in my case. These combinations never helped me feel like myself prior to getting hypothyroidism. I have learned that t4 by itself is the absolute best therapy for hypothyroidism. If you are not feeling good taking t4 alone you are either taking to much or to little. This is why a specialist in thyorid disorders is required. Normal levels of tsh range in most labs between .5 and 5.0. Unfortunatley allot of pcp will claim you are euthroid when you levels fall anywhere in between these numbers. You may draw a tsh of 3.0 but in reality your body runs optimaly at a 2.0 You will continue to feel crappy even with slighty elevated tsh levels over your normal, not he labs normal. SO my advice to all of you through experience is get of the t4 get with a professional thyroid specialist and take t4 until youo feel good again. I would give it at least 6 months of trail and error. You will also need to look out for seasonal changes. When the seasons change your thyroid levels could change also and meds need to be adjusted. I have my tsh screening done every six weeks so I know that my tsh is around 2.0 When winter hits I usually have to increase my dose considerably
T3 Therapy: An Option When T4 Isn’t Working for You
I’m writing this article so that you can have information which might be of benefit to you. I was going to wait until I had been on the protocol for a year, but, what the heck, I thought I’d get the information out there so that others might read it and evaluate it for themselves.
A brief history about me: I’m a clinical laboratory scientist. I had been taking T4 medication for 6 years and just got worse, tried Armour and couldn’t tolerate it (side effects of jitteriness, high BP, clamminess). I fired my MD and endocrinologist and hired an ND. He started my on time-release T3 and, after two weeks, my symptoms of fatigue, constipation, inability to concentrate, weight gain, coldness, peeling nails, thinning hair, etc., started to improve tremendously. Now I can concentrate again, have energy to do things, have normal digestion, and have hope that SOMETHING is working! It’s been two months now, not a long time I know.
The way this method works is that I started on a low dose of 7.5 mcg and increased until I felt better. I am now slowly reducing the dose and weaning off of the medicine. The theory is that one’s own thyroid can begin producing and using its own thyroid hormone.
As I understand it, the rationale for this treatment is that, for some people, stress such as childbirth, loss of a loved one, divorce, loss of a job, etc., can cause them to produce an excess of reverse T3, a molecule similar to the active form of the hormone, T3. This reverse T3 blocks cell receptors and prevents active T3 from entering cells and functioning normally. The result is a generalized slowdown of metabolism and the accompanying hypothyroid symptoms so familiar to us all.
Some people are able to reset their thyroid hormone balance without medication; others can’t and so get locked into the vicious cycle of producing more and more reverse T3 and shutting down their rate of metabolism even more.
On this protocol you may have noticed that T4 is taken out of the equation. This is because T4 is used by the body to make T3; but it is also used to make reverse T3. In order to reduce the amount of reverse T3 being made, it is necessary to stop taking T4. The idea is that the reverse T3 which is blocking cell receptor sites will be cleared so that active T3 can enter the cells.
There is a bit of controversy about this method. What protocol which deviates from the one-pill-for-all philosophy of mainstream medicine hasn’t caused a bit of controversy? Most mainstream doctors either aren’t aware of this protocol or don’t want to take the risk of going against the status quo of prescribing T4 and doing annual TSH tests. The controversy stems from the fact that the doctor who developed this protocol, Dr. E. Denis Wilson, named it after himself. Yet, how many doctors and researchers name syndromes and protocols after themselves? Think Heimlich maneuver for one. (Sorry, but I felt we needed a little chuckle here.)
If you have been reading the scientific literature and the forums, you will have probably noticed that no one protocol works for everybody. Some find success with T4-only therapy, some with Armour, some with T3 added to T4, some with T3 only. I fall into this last group. It wasn’t until I stopped my T4 (which was a bit scary because I had been on it for six years) and started the T3.
Time-release T3 works for me, releasing T3 into the bloodstream at a slow, steady, constant rate. Other T3 meds, such as Cytomel, often cause side effects, probably because they release T3 all at once. T3 is a very powerful hormone. It directs the complex machinery of cell metabolism, signaling every organ system and cell to function: brain, bowels, muscle, sugar and fat metabolism, skin, hair, nails. No wonder the symptoms of hypometabolism and hypothyroidism are so varied and complex. And, if left untreated, hypothyroidism can cause such severe problems as infertility, heavy menstrual bleeding, atherosclerosis and high cholesterol levels, depression, skin problems and arthritis, to name a few. Every body system is affected by the malfunctioning of the thyroid system. No wonder we feel as if we are dead, have no energy, can’t think straight, gain weight and feel sluggish and achy and overweight and cold.
I hope this information helps those of you for whom T4-only therapy or Armour have not worked.
If you would like more information, you can contact me at welte2@comcast.net.
Judy
Jo, this is great! I'm not sure why some doctors are so dogmatic, but I am grateful that I have a wonderful doctor for my fibromyalgia, who told me straight out that synthetic thyroid would not work for me, as I needed the T4/T3 combination, due to my T4/T3 ratios as a result of a more definative blood test (yes, I had tested borderline for years! I have it compounded for me, not sure what its made of, and I don't really care! She told me it would take about a year to see the full effects, as she had to slowly increase the dosage, then back it off when she had it a little too high. I have to say she was absolutely right, and I thank her with a full grateful heart! I could finally lose a little weight, stop scratching myself bloody, and my hair even started to grow a little, and have more energy & stamina, even with fibro!
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